Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas (2)
| Status: | Terminated |
|---|---|
| Conditions: | Ocular, Dermatology |
| Therapuetic Areas: | Dermatology / Plastic Surgery, Ophthalmology |
| Healthy: | No |
| Age Range: | 8 - Any |
| Updated: | 10/13/2018 |
| Start Date: | December 1, 2009 |
| End Date: | April 30, 2017 |
Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas
To evaluate the efficacy of ultraviolet-A (UVA)-induced cross-linking of corneal collagen
(CXL) as a method to increase the biomechanical and biochemical stability of the cornea by
inducing additional cross-links within or between collagen fibers using UVA light and the
photo- mediator riboflavin. The purpose of this study is to generate data for presentation at
medical meetings and for peer-review publication
(CXL) as a method to increase the biomechanical and biochemical stability of the cornea by
inducing additional cross-links within or between collagen fibers using UVA light and the
photo- mediator riboflavin. The purpose of this study is to generate data for presentation at
medical meetings and for peer-review publication
Inclusion Criteria:
- 8 years of age or older
- Diagnosis of keratoconus, post-LASIK ectasia, or pellucid marginal degeneration or
forme fruste pellucid marginal degeneration.
- Diagnosis of FFKC
- History of Radial Keratotomy with fluctuating vision.
- Ability to provide written informed consent
- Likely to complete all study visits
- Minimum corneal thickness of at least 300 measured by ultrasound or Pentacam
Exclusion Criteria:
- Severe corneal scarring that markedly affects vision
- Contraindications to any study medications or their components
- Pregnancy or breast feeding
- Active Herpes Corneal Disease
We found this trial at
5
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