Apoptotic Cell (AC) Uptake by Human Alveolar Macrophages (AM)
| Status: | Completed |
|---|---|
| Conditions: | Chronic Obstructive Pulmonary Disease, Pulmonary |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - 80 |
| Updated: | 4/21/2016 |
| Start Date: | February 2010 |
| End Date: | December 2015 |
Apoptotic Cell Ingestion by Normal Human Alveolar Macrophages
The purpose of this study is to compare the ability of two types of white blood cells to eat
dead host cells, and how this process affects their ability to protect the body from
infection. The two cell types are monocytes, a cell in the bloodstream, and alveolar
macrophages, a cell in the lung that is ultimately derived from monocytes
dead host cells, and how this process affects their ability to protect the body from
infection. The two cell types are monocytes, a cell in the bloodstream, and alveolar
macrophages, a cell in the lung that is ultimately derived from monocytes
Volunteers, who may be Veterans or non-Veterans, will be screened by a series of
questionnaires, chest X-ray, spirometry, EKG, blood work, and a complete history and
physician examination by a study physician. Those who qualify for the study and agree via
informed consent, will undergo a fiberoptic bronchoscopy on a separate day for the initial
visit. Bronchoscopy is a procedure in which a flexible video instrument is passed via the
nose or mouth, through the vocal cords and into the lungs. During the procedure, portions of
the lungs will be washed ("lavaged") with a salt water solution, to collect the alveolar
macrophages. This procedure involves conscious sedation, so that a driver is required on the
day of the bronchoscopy. The entire procedure, including placement of an intravenous line to
administer medications, local anesthetics, the bronchoscopy itself, and the recovery period,
takes about 2.5-3 hours. The cells collected by bronchoscopy will be studied in the research
laboratory, and used entirely in that procedure.
questionnaires, chest X-ray, spirometry, EKG, blood work, and a complete history and
physician examination by a study physician. Those who qualify for the study and agree via
informed consent, will undergo a fiberoptic bronchoscopy on a separate day for the initial
visit. Bronchoscopy is a procedure in which a flexible video instrument is passed via the
nose or mouth, through the vocal cords and into the lungs. During the procedure, portions of
the lungs will be washed ("lavaged") with a salt water solution, to collect the alveolar
macrophages. This procedure involves conscious sedation, so that a driver is required on the
day of the bronchoscopy. The entire procedure, including placement of an intravenous line to
administer medications, local anesthetics, the bronchoscopy itself, and the recovery period,
takes about 2.5-3 hours. The cells collected by bronchoscopy will be studied in the research
laboratory, and used entirely in that procedure.
Inclusion Criteria:
- Veteran or non-Veteran
- Able to give informed consent
Exclusion Criteria:
- Unstable heart disease
- Other systemic disease and unlikely to survive at least 2 years
- Mental incompetence
- Prednisone >20 mg/day
- Participation in another interventional protocol within last 6 weeks
- Asthma
- Cystic fibrosis
- Clinically significant bronchiectasis
- Lung cancer or any cancer not in remission for at least 5 years
- Other inflammatory or fibrotic lung disease
- Use of antibiotics for a lung infection within the past 4 weeks
- Autoimmune disease, i.e., Rheumatoid arthritis, systemic lupus erythematosus,
autoimmune hepatitis, Crohn's disease or other
We found this trial at
1
site
Click here to add this to my saved trials
