Transcranial Direct Current Stimulation (tDCS) and Parkinson's Disease
Status: | Archived |
---|---|
Conditions: | Parkinsons Disease |
Therapuetic Areas: | Neurology |
Healthy: | No |
Age Range: | Any |
Updated: | 7/1/2011 |
Start Date: | January 2010 |
End Date: | June 2011 |
Can Transcranial Direct Current Stimulation (tDCS)Modulate Protective Stepping and Gait Performance of People With Parkinson's Disease
The use of low level electrical stimulation when applied over the head, also called
transcranial direct current stimulation (tDCS), is being tested by several groups of
researchers to see if tDCS can improve movements of persons with damage to the brain. The
safety and potential benefits of tDCS to children or adults patients who are paralyzed
because of brain damage are reported in the medical literature. In addition, some patients
with Parkinson's disease (PD) experience improvement in memory and report better use of the
hand after tDCS. The treatment requires putting electrodes (pads) over the head and sending
very small amount of electrical current that the patient may feel as "little tingling".
Application of tDCS takes 20 min. In this study we wish to test if tDCS application can
improve stepping and walking ability of subjects with PD and if the improvement is the same
as when walking on treadmill. We plan to test the subject's ability to step when pulled by a
laboratory testing system and also test his/her walking ability. There will be 3 sessions 7
days apart. In the first session the subject will be tested then treated for 20 min with
tDCS and then tested again. In the second session the subject will be tested then walk on a
treadmill for 20 min then tested again. In the third session the subject will be tested then
walk on the treadmill for 20 min while receiving also tDCS and tested one last time at the
end of the session. Each session will take between 2 and 3 hours.
Recent advances in non-invasive electrical stimulation technology including transcranial
direct current stimulation (tDCS) have provided novel and low risk options to rehabilitate
the impaired ability of the central nervous system (CNS) to process sensorimotor
information. Furthermore, tDCS appears to enhance CNS connectivity.and there is preliminary
evidence that indicates that patients with Parkinson's Disease (PD) may experience
improvement in working memory, the Unified Parkinson's Disease Rating Scale, simple reaction
time and the Purdue Pegboard test. tDCS is inexpensive, portable and available for repeated
home use. It may provide long-lasting enhancement of cortical activity in part because tDCS
is easy to administer to facilitate frequent and can be combined with other rehabilitation
approaches including posture and gait training. However to date, no study has examined
quantitatively the effects of tDCS on posture control and walking ability in patients with
PD. As a first step we plan to identify the immediate effects of tDCS, as well as the added
value of tDCS to treadmill exercise training, to improve posture and gait of individuals
with PD.
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