Effects of Almonds on Cardiovascular Risk Factors
| Status: | Completed |
|---|---|
| Conditions: | Peripheral Vascular Disease |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 2/4/2013 |
| Start Date: | September 2009 |
| End Date: | December 2011 |
| Contact: | Claire E Berryman |
| Email: | psudiet@gmail.com |
| Phone: | 814-863-8109 |
Effects of a Diet Rich in Almonds on LDL Cholesterol, LDL Particle Size, Abdominal Adiposity and Vascular Health
The purpose of this research is to build the evidence base for approval of FDA health claims
related to almonds and CVD. A randomized, 2-period, crossover controlled feeding study was
designed to compare the effects of two blood cholesterol lowering diets that meet the AHA
recommendations. The nutrient profiles of the control diet (no almonds/day) and almond diet
(1.5 oz. of almonds/day) are matched for protein, saturated fat, and cholesterol. The study
population consists of two cohorts of 25 men and women with moderately elevated LDL-C. The
investigators hypothesize that a cholesterol-lowering diet designed with almonds confers
greater cardioprotective effects than a cholesterol-lowering diet without almonds on the
basis of the LDL-C lowering response, effect on LDL particle size, abdominal adiposity and
vascular health.
Inclusion Criteria:
- BMI (20-35)
- Low density lipoprotein cholesterol males (128-194mg/dL) and females (121-190 mg/dL)
Exclusion Criteria:
- Pregnant, planning to become pregnant, or lactating
- Smoking; cholesterol-lowering medication
- Glucose-lowering medication
- Over the counter cholesterol-lowering substances (e.g.: psyllium, fish oil, soy
lecithin, phytoestrogen)
- The following medical conditions:
- heart disease
- stroke
- TIA
- blood pressure >140/90
- diabetes
- renal or kidney disease
- rheumatoid arthritis
- blood clotting disorder
- liver disease or cirrhosis
- compromised immune system
- peripheral vascular disease or circulation problems
*> 10% body weight loss in the past 6 months
- vegetarian
- nut allergies
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