Prandial Insulin Dosing in Hospitalized Patients

The purpose of this study is to determine whether mealtime insulin, dosed to match the intake
of carbohydrates (starches or sugars) results in better control of blood sugar than a fixed
meal dose in hospitalized patients.

Inclusion Criteria:

- general medical or minor surgical hospitalized patients

- type 2 diabetes

- blood glucose 150-400 on at least 2 occasions within 24 hours or requiring at least 20
units of insulin/day in the 24 hours prior to enrollment

Exclusion Criteria:

- • Major surgery, occurring within the previous 2 weeks or planned within 72 hours of
study entry, including cardiothoracic, neurosurgical, and open intra-abdominal
procedures (in particular, any surgery lasting over 2 hours).

- Patients receiving glucocorticoids, total parental nutrition (TPN), or tube
feeds.

- Pregnancy (glucose targets differ in pregnancy). Premenopausal women not on
pharmacologic contraceptives, inrauterine device (IUD), or surgical menopause
will undergo pregnancy testing.

- Patients currently on IV insulin (must wait to enroll) or with planned surgical
procedures in the next 72 hours for whom intravenous insulin will be likely

- Prolonged (>24 hour) strict nil per os (NPO-nothing by mouth) status (eg. small
bowl obstruction). Liquid or modified consistency diets are acceptable.

- Patients for whom expected length of stay will be less than 48 hours

- Patients using subcutaneous insulin pumps

- Diabetic ketoacidosis

- End-stage renal disease on dialysis

- End-stage liver disease with cirrhosis

- Mental conditions precluding informed consent

- Potentially sensitive admissions: prisoners, HIV, suicidality

- Unable to give consent in English