Vitamin D Supplementation and Acute Respiratory Infection in Older Long-Term Care Residents
| Status: | Completed |
|---|---|
| Conditions: | Food Studies, Pulmonary |
| Therapuetic Areas: | Pharmacology / Toxicology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 60 - Any |
| Updated: | 5/3/2014 |
| Start Date: | May 2010 |
| End Date: | August 2015 |
| Contact: | Adit A Ginde, MD, MPH |
| Email: | adit.ginde@ucdenver.edu |
| Phone: | 720-848-6777 |
This study will test the role of high dose vitamin D supplementation in prevention of acute
respiratory infection in older nursing home residents. The investigators hypothesize that
residents on high dose vitamin D supplementation will have a lower incidence of acute
respiratory infection that those on standard dose vitamin D supplementation.
respiratory infection in older nursing home residents. The investigators hypothesize that
residents on high dose vitamin D supplementation will have a lower incidence of acute
respiratory infection that those on standard dose vitamin D supplementation.
Inclusion Criteria:
- Age 60+ years
- Resides in nursing home
Exclusion Criteria:
- Terminal illness (expected survival <6 months)
- Anticipated discharge within 12 months
- Unable to take whole or crushed tablets
- Active cancer, except squamous/basal cell carcinoma
- Severe malnutrition (body mass index <18 kg/m2)
- Current immunosuppressive medications (including corticosteroids)
- Renal failure (estimated glomerular filtration rate < 15 mL/min/1.73m2)
- Currently taking >1,000 IU/d vitamin D supplementation
- History (or strong family history) of kidney stones
- History of sarcoidosis or other granulomatous disorders associated with hypercalcemia
- Elevated baseline hypercalcemia (albumin-adjusted serum calcium >10.5 mg/dL)
- Baseline serum 25OHD level ≥ 100 nmol/L
- Inability to provide informed consent and no available healthcare legally authorized
representative
- Inability of participant or legally authorized representative to speak/understand
English
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