Women With Cancer: An Exercise Study to Promote Health
| Status: | Completed |
|---|---|
| Conditions: | Cancer, Cancer, Orthopedic |
| Therapuetic Areas: | Oncology, Orthopedics / Podiatry |
| Healthy: | No |
| Age Range: | 18 - 75 |
| Updated: | 7/11/2015 |
| Start Date: | January 2008 |
| End Date: | August 2012 |
An Exercise Intervention to Improve Health in Postmenopausal Cancer Survivors
The purpose of the study is to evaluate the effect of an aerobic-resistance exercise program
compared to a home based physical activity program on bone mass, body composition, metabolic
risk factors and cardiovascular fitness in women with cancer who have completed therapy.
compared to a home based physical activity program on bone mass, body composition, metabolic
risk factors and cardiovascular fitness in women with cancer who have completed therapy.
The proposed study will evaluate an endurance-resistive exercise intervention to attenuate
the effects of menopause and cancer treatment (bone loss, increased body fat, decreased lean
muscle mass, weight gain, decreased physical activity) in an at-risk population of female
cancer survivors. Women with solid tumors (breast, gynecological, colo-rectal) and lymphoma
who have completed primary and/or adjuvant therapy within the past three years and who are
perimenopausal or early postmenopausal and any woman on an Aromatase Inhibitor will be
recruited to participate in a randomized controlled trial (RCT) of a 12 month exercise
intervention (N=75) versus a health promotion control group (N=75). The specific aims of the
study are to: (1) examine the effects of an exercise intervention on bone mass (serum
biomarkers, lumbar spine, hip DEXA) and body composition (whole body DEXA, weight, waist
circumference), (2) examine the effect of an exercise intervention on metabolic risk
factors (lipids, cholesterol, fasting glucose, insulin resistance, Hemoglobin A1-C, and
blood pressure), and (3) examine the effects of an exercise intervention on functional
status and cardiovascular fitness (exercise stress test).
the effects of menopause and cancer treatment (bone loss, increased body fat, decreased lean
muscle mass, weight gain, decreased physical activity) in an at-risk population of female
cancer survivors. Women with solid tumors (breast, gynecological, colo-rectal) and lymphoma
who have completed primary and/or adjuvant therapy within the past three years and who are
perimenopausal or early postmenopausal and any woman on an Aromatase Inhibitor will be
recruited to participate in a randomized controlled trial (RCT) of a 12 month exercise
intervention (N=75) versus a health promotion control group (N=75). The specific aims of the
study are to: (1) examine the effects of an exercise intervention on bone mass (serum
biomarkers, lumbar spine, hip DEXA) and body composition (whole body DEXA, weight, waist
circumference), (2) examine the effect of an exercise intervention on metabolic risk
factors (lipids, cholesterol, fasting glucose, insulin resistance, Hemoglobin A1-C, and
blood pressure), and (3) examine the effects of an exercise intervention on functional
status and cardiovascular fitness (exercise stress test).
Inclusion Criteria:
- Female
- Cancer diagnosis
- Postmenopausal
Exclusion Criteria:
- Health condition contraindication to moderate physical activity
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