Role of Immune System in Obesity-related Inflammation and Cardiometabolic Risk (201102127)



Status:Active, not recruiting
Conditions:Obesity Weight Loss, Endocrine, Gastrointestinal
Therapuetic Areas:Endocrinology, Gastroenterology
Healthy:No
Age Range:18 - 90
Updated:9/8/2018
Start Date:April 2010
End Date:September 2020

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Trial Summary
Trial Overview
Inclusion Criteria
The purpose of this study is to learn more about how the body stores fat in and around organs
(ex. the liver) and why this affects some people's health more than others. Understanding
this may lead to better treatments for diseases such as diabetes and cardiovascular disease.

The purpose of this study is to determine the specific cellular and organ system metabolic
and immunologic alterations that are associated with insulin resistance and inflammation in
order to identify putative mechanisms and novel bio-markers involved in the pathogenesis and
progression of inflammatory and cardiometabolic diseases.

Inclusion Criteria:

- must be sedentary (regular exercise <1 h/week or <2 times/week for the last 2 months)

Exclusion Criteria:

- active or previous history of other liver diseases

- history of alcohol abuse

- currently consuming ≥20 g alcohol/day

- diabetes

- severe hypertriglyceridemia (>300 mg/dL)

- smoke tobacco

- medications that might confound the study results

- pregnancy or lactation
We found this trial at
1
site
Washington University School of Medicine
660 S Euclid Ave
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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mi
from
Saint Louis, MO
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