Genetics of Motor Learning
| Status: | Terminated |
|---|---|
| Conditions: | Parkinsons Disease, Neurology, Orthopedic |
| Therapuetic Areas: | Neurology, Orthopedics / Podiatry |
| Healthy: | No |
| Age Range: | 18 - 100 |
| Updated: | 3/20/2019 |
| Start Date: | April 14, 2010 |
| End Date: | December 21, 2015 |
Background:
- New studies in human genetics have revealed information about genetic connections to memory
and motor behavior. Researchers are interested in investigating the role of genetics in motor
learning, in conjunction with related studies taking place in the Human Motor Control Section
of the National Institute of Neurological Diseases and Stroke (NINDS). Participants in motor
learning studies conducted at NINDS will be asked to provide blood samples for further
evaluation.
Objectives:
- To create a repository of blood samples from patients and healthy subjects who are
participating in NINDS motor learning studies.
Eligibility:
- Individuals between 18 and 100 years of age who are or will be participating in motor
learning research studies at the National Institutes of Health.
Design:
- Blood draws for genetic testing will usually be done on the same day as the motor
learning study. Participants will provide one blood sample for research.
- No treatment will be provided under this study....
- New studies in human genetics have revealed information about genetic connections to memory
and motor behavior. Researchers are interested in investigating the role of genetics in motor
learning, in conjunction with related studies taking place in the Human Motor Control Section
of the National Institute of Neurological Diseases and Stroke (NINDS). Participants in motor
learning studies conducted at NINDS will be asked to provide blood samples for further
evaluation.
Objectives:
- To create a repository of blood samples from patients and healthy subjects who are
participating in NINDS motor learning studies.
Eligibility:
- Individuals between 18 and 100 years of age who are or will be participating in motor
learning research studies at the National Institutes of Health.
Design:
- Blood draws for genetic testing will usually be done on the same day as the motor
learning study. Participants will provide one blood sample for research.
- No treatment will be provided under this study....
OBJECTIVE:
The objective of this study is to create a bio-repository of blood samples from patients and
healthy subjects who are participating in NINDS motor learning studies. Blood will be
analyzed for BDNF and samples stored for future genetic studies. . A variety of genes that
may affect motor learning are being increasingly identified, and variations among these
genes, referred to as polymorphisms, may help explain individual differences.
STUDY POPULATION:
We will enroll up to five hundred healthy volunteers and five hundred volunteers with
movement difficulties who are between the ages of 18 and 100 and who are already
participating, or will be participating, in other protocols dealing with motor learning
research studies at the National Institutes of Health (NIH).
DESIGN:
This is an observational and repository protocol that involves a single blood sample for
genetic analysis. This will allow the genetic characterization of subjects participating in
motor learning protocols to be analyzed and tested for the role of genetics in motor learning
results.
OUTCOME MEASURE:
We will compare genetic variations with the different behavioral, electrophysiologic,
imaging, or other outcomes acquired in the associated motor learning studies. Thus, we will
determine whether specific polymorphisms are associated with different measures of motor
learning.
The objective of this study is to create a bio-repository of blood samples from patients and
healthy subjects who are participating in NINDS motor learning studies. Blood will be
analyzed for BDNF and samples stored for future genetic studies. . A variety of genes that
may affect motor learning are being increasingly identified, and variations among these
genes, referred to as polymorphisms, may help explain individual differences.
STUDY POPULATION:
We will enroll up to five hundred healthy volunteers and five hundred volunteers with
movement difficulties who are between the ages of 18 and 100 and who are already
participating, or will be participating, in other protocols dealing with motor learning
research studies at the National Institutes of Health (NIH).
DESIGN:
This is an observational and repository protocol that involves a single blood sample for
genetic analysis. This will allow the genetic characterization of subjects participating in
motor learning protocols to be analyzed and tested for the role of genetics in motor learning
results.
OUTCOME MEASURE:
We will compare genetic variations with the different behavioral, electrophysiologic,
imaging, or other outcomes acquired in the associated motor learning studies. Thus, we will
determine whether specific polymorphisms are associated with different measures of motor
learning.
- INCLUSION CRITERIA:
Anyone aged 18-100 years and participating in a motor learning study at NIH is eligible to
participate in this study.
EXCLUSION CRITERIA:
Anyone with impaired decisional capacity, inability to provide informed consent, or who is
unable to safely give blood is not eligible to participate in this study.
We found this trial at
1
site
9000 Rockville Pike
Bethesda, Maryland 20892
Bethesda, Maryland 20892
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