Functional Magnetic Resonance Imaging (fMRI) Studies in Pathological Gambling (PG) and Obsessive-Compulsive Disorder (OCD)

This study will explore the brain processes associated with inhibition and rewards in
pathological gamblers and people with obsessive compulsive disorder. Participants who are
diagnosed with PG or OCD will undergo one fMRI scan, and those entering treatment with
topiramate will undergo two fMRI scans, one at the start of the study and one at termination
(approximately 12-14 weeks later). The brain scan will last about one and a half hours and
will involve performing tasks while in the scanner. Participants must be between the ages of
18-55 and in good medical condition.