Integrated Whole-Genome Analysis of Hematologic Disorders
| Status: | Completed |
|---|---|
| Conditions: | Blood Cancer, Hematology |
| Therapuetic Areas: | Hematology, Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 6/2/2018 |
| Start Date: | September 2009 |
| End Date: | August 2, 2013 |
Integrated Whole-Genome Analysis of Hematologic Disorders Using High-Throughput Sequencing and Array Technologies
We will use new technologies to look at the DNA, RNA, proteins, and metabolites in the
disease-containing blood, bone marrow, or tissue and normal cells from the skin. Our goal is
to analyze all of the genes in the diseased and normal skin sample. By comparing the results
of the diseased sample and normal skin cells and the results of the two types of genetic
information (DNA and RNA), we should be able to identify genetic changes that are important
for the initiation, progression, or treatment response of that particular disorder.
disease-containing blood, bone marrow, or tissue and normal cells from the skin. Our goal is
to analyze all of the genes in the diseased and normal skin sample. By comparing the results
of the diseased sample and normal skin cells and the results of the two types of genetic
information (DNA and RNA), we should be able to identify genetic changes that are important
for the initiation, progression, or treatment response of that particular disorder.
Inclusion Criteria:
1. 18 years of age or older
2. Patient meets the clinical and/or pathologic criteria for the hematologic disorder
being examined.
3. Patient is willing to provide a skin biopsy and five 10 mL tubes of peripheral blood.
Exclusion Criteria:
1. Less than 18 years of age
2. Patient is not willing to provide a skin biopsy and five 10 mL tubes of peripheral
blood.
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