Selenium Supplementation of Patients With Cirrhosis



Status:Archived
Conditions:Gastrointestinal
Therapuetic Areas:Gastroenterology
Healthy:No
Age Range:Any
Updated:7/1/2011

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Human Selenium Nutritional Requirement and Biomarkers in Health and Disease


This study is being conducted to determine if patients with cirrhosis (liver disease) are
selenium deficient. The effect of supplementation with two chemical forms of selenium on
plasma selenium biomarkers will be determined and correlated with the severity of the liver
disease.


Selenium is an essential nutrient that plays a role in oxidant defense, among other
functions. There is much interest in the role selenium may play in several disease
processes. It is possible that certain diseases result in selenium deficiency because of the
form of selenium taken in the normal diet.

We propose to measure the selenium biomarkers associated with supplemental intakes of 200 or
400 µg of selenium per day in the chemical form selenate, or with supplemental intake of 200
µg selenium as selenomethionine. 144 patients with cirrhosis will be randomized to one of 4
treatment groups, including a placebo. After treatement for 4 weeks, all participants will
receive 400 µg of selenium per day as selenate for 4 weeks. Blood will be measured initially
and at 4 and 8 weeks. Selenium, selenoprotein P and glutathione peroxidase will be measured
in the plasma.


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Ventura, California 93003
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Ventura, CA
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