Trial of Doxycycline to Reduce Sputum MMP-9 Activity in Adult Cystic Fibrosis (CF) Patients
| Status: | Completed |
|---|---|
| Conditions: | Pulmonary |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 19 - Any |
| Updated: | 10/14/2017 |
| Start Date: | November 2008 |
| End Date: | November 2012 |
A Randomized Trial of Doxycycline to Reduce Sputum MMP-9 Activity in Adult CF Patients Hospitalized for Pulmonary Exacerbations
The purpose of this study is to examine the role of a well-known and well-tolerated
antibiotic, doxycycline, in the treatment of cystic fibrosis patients who are hospitalized.
This antibiotic does not effectively treat the bacteria in airways of cystic fibrosis
patients, but may reduce the activity of inflammatory molecules in the disease.
antibiotic, doxycycline, in the treatment of cystic fibrosis patients who are hospitalized.
This antibiotic does not effectively treat the bacteria in airways of cystic fibrosis
patients, but may reduce the activity of inflammatory molecules in the disease.
One molecule that is inhibited by doxycycline is matrix metalloprotease-9, which is emerging
as an important mediator of lung inflammation and damage in cystic fibrosis. We hypothesize
that the addition of treatment with doxycycline in CF inpatients will reduce MMP-9 activity
and inflammatory markers in the sputum of cystic fibrosis patients compared to CF patients
not treated with doxycycline.
as an important mediator of lung inflammation and damage in cystic fibrosis. We hypothesize
that the addition of treatment with doxycycline in CF inpatients will reduce MMP-9 activity
and inflammatory markers in the sputum of cystic fibrosis patients compared to CF patients
not treated with doxycycline.
Inclusion Criteria:
- Cystic Fibrosis
- Hospitalization for Pulmonary exacerbation
Exclusion Criteria:
- Significant GI illness
- Participation in another Investigational Protocol
- Allergies to Doxycycline
- Sputum Culture only positive for Staphylococcus aureus,
- Pregnant or Nursing
- Unwilling to use effective birth control
- Elevated LFT's greater than 3x the upper limit of normal
- Creatinine greater than 1.5x the upper limit of normal
- Lung transplantation
- Substance abuse within 30 days of screening
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University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
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