Study to Assess Safety, Tolerability and PK of AZD1480 in Patients With Solid Tumours
| Status: | Completed |
|---|---|
| Conditions: | Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 9/23/2012 |
| Start Date: | April 2010 |
| End Date: | August 2013 |
| Contact: | AstraZeneca Clinical Study Information |
| Email: | information.center@astrazeneca.com |
| Phone: | 800-236-9933 |
A Phase I, Open-Label, Multi-Center, Dose-Escalation Study to Assess the Safety and Tolerability, and Pharmacokinetics of AZD1480 Administered as Daily Oral Monotherapy in Patients With Advanced Solid Malignancies in the Escalation Phase and EGFR or ROS Mutant NSCLC or Non-Smokers With Lung Metastasis in the Expansion Phase.
This study is being conducted to assess the safety, tolerability and PK of AZD1480 in
patients with advanced solid malignancies.
Inclusion Criteria:
- Patients with advanced solid cancer without available therapy in the escalation
phase and mutation positive NSCLC or non-smokers with other primary tumors lung
metastasis in the expansion phase
- ECOG Performance Status 0-1
- Evidence of post-menopausal status in females or males willing to use barrier
contraception
Exclusion Criteria:
- Prior therapy with any JAK2 medications
- Significant lung disorder or lung disease. Previous radiation therapy to chest wall
or chest infection requiring antibiotic treatment within 21 days before study
screening. Evidence of significant pulmonary hypertension or COPD
- Eye disease of the cornea
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