Genetic Modifiers of Cystic Fibrosis Related Diabetes
| Status: | Recruiting |
|---|---|
| Conditions: | Pulmonary, Diabetes |
| Therapuetic Areas: | Endocrinology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | Any - 99 |
| Updated: | 12/9/2018 |
| Start Date: | April 2008 |
| End Date: | April 2020 |
This research is being done to find the genes and other factors that are responsible for
differences among persons with cystic fibrosis. We are particularly interested in the factors
that relate to the development of Cystic Fibrosis Related Diabetes (CFRD).
differences among persons with cystic fibrosis. We are particularly interested in the factors
that relate to the development of Cystic Fibrosis Related Diabetes (CFRD).
The study is recruiting people with cystic fibrosis (CF). The medical record is being
extracted, and a blood sample is taken for DNA. The DNA samples are tested for variation both
at the CFTR gene (the CF gene) and over the entire rest of the genome. Using large numbers of
people with CF, and knowing who does and does not have CFRD, we identify genetic variations
that associate with CFRD. Knowing these variations allows us to better understand the causes
of CFRD, and with enough information, better to predict CFRD and identify people at
particularly high or low risk of CFRD. People participating in this study also have the
option to participate in related studies of other metabolic traits in CF such as over- and
underweight.
extracted, and a blood sample is taken for DNA. The DNA samples are tested for variation both
at the CFTR gene (the CF gene) and over the entire rest of the genome. Using large numbers of
people with CF, and knowing who does and does not have CFRD, we identify genetic variations
that associate with CFRD. Knowing these variations allows us to better understand the causes
of CFRD, and with enough information, better to predict CFRD and identify people at
particularly high or low risk of CFRD. People participating in this study also have the
option to participate in related studies of other metabolic traits in CF such as over- and
underweight.
Inclusion Criteria:
- Any person with Cystic Fibrosis and his/her parents.
Exclusion Criteria:
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