Assessment of Gastric Emptying Speed in Patients Who Experience Diarrhea Following a Trigger Meal
| Status: | Archived |
|---|---|
| Conditions: | Irritable Bowel Syndrome (IBS), Gastrointestinal |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | April 2010 |
| End Date: | April 2011 |
Pilot Study: Assessment of Gastric and Intestinal Motility Following a Trigger Meal in Patients With Post Prandial Diarrhea
The rapid diarrhea that patients experience who have diarrhea occurring after eating
specific foods may be causing a "physiologic gastric dumping syndrome". This means that
rather than the food being kept in the stomach for normal digestion, it rapidly goes into
the small intestine and diarrhea occurs. This study is designed to measure how fast the
food empties from the stomach when a person with this problem consumes a "regular diet",
compared to a meal with a "triggering substance". Each participant will swallow a radio
frequency capsule that with the different meals that will show how fast the food is
traveling through the intestines in the different situations.
Since some patients have found that pancreatic enzymes seem to ameliorate this diarrhea from
occurring,willing participants will be asked to duplicate the "triggering meal" 2 more
times. Once taking a pancreatic enzyme (active drug) with the meal and a second time taking
an identical placebo. Neither the participant nor the study investigator will know which
capsule is the active drug in this phase of the study. Willing participants will receive a
small stipend each time they swallow the radio frequency capsule. This capsule is large,
approximately twice the size of a vitamin pill so individuals must have no difficulties with
swallow to participate nor any history of bowel obstruction or major surgery to the
abdominal which might have caused adhesions.
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