Study of Selumetinib (AZD6244)(ARRY-142886) in Combination With Irinotecan in Previously Treated Patients With Colorec



Status:Archived
Conditions:Colorectal Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:Any
Updated:7/1/2011
Start Date:April 2010
End Date:December 2011

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A Dose Finding and Phase II Study of Selumetinib (AZD6244) (Hyd-Sulfate) in Combination With Irinotecan, in 2nd Line Patients With K-ras or B-raf Mutation Positive Advanced or Metastatic Colorectal Cancer


The purpose of this study is to determine whether treatment with Selumetinib (AZD6244)
(Hyd-Sulfate) in combination with Irinotecan as a second treatment in patients with K-ras
or B-raf mutation will prevent tumor progression and prolong progression free survival.


A Dose Finding and Phase II Study of Selumetinib (AZD6244) (Hyd-Sulfate) in Combination
with Irinotecan, in 2nd Line Patients with K-ras or B-raf Mutation Positive Advanced or
Metastatic Colorectal Cancer


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