A Safety & Efficacy Study of BGS649 in Women With Refractory Endometriosis

Inclusion Criteria:

- Must have surgical diagnosis of endometriosis est. w/in 5 years before screening.
Subjects must have self reported moderate to severe pelvic pain at screening to be
confirmed during the run-in-phase

- Subjects with moderate to severe pelvic pain who were refractory to surgery
(persistent or recurrent pelvic pain within 24 months after any therapeutic surgery)
and at least two hormonal therapies from two different classes, including one approved
hormonal therapy

Exclusion Criteria:

- Subjects who have undergone hysterectomy or bilateral oophorectomy.

- Surgical treatment of endometriosis within 3 months before screening.

- Subjects who are pregnant or who were pregnant within 3 months of visit one.

- Subjects who are nursing or lactating

- Subjects who are tobacco smokers.

Other protocol-defined inclusion/exclusion criteria may apply