Childhood Cancer Survivor Study

The study will focus on the following objectives:

- Characterize survivors' health with respect to disease- and treatment-related factors.

- Investigate the consequences of various intensities of exposure to chemotherapy and/or
radiation on health outcomes (e.g., cardiovascular, reproductive, second cancers, etc…).

- Compare the mortality experience of survivors with the general population.

- Characterize the health-related behaviors, patterns of medical care, and medical
follow-up needs of survivors.

- Describe patterns of familial aggregation of cancer, including known (and variations of)
cancer family syndromes.

- Collect and store biologic samples (saliva, blood, second tumor tissue) to correlate
with health outcomes and use for future research.

Inclusion Criteria:

Initial Cohort:

- Five-year survival following diagnosis of leukemia, lymphoma, CNS tumor, bone tumor,
Wilms tumor, neuroblastoma, or soft tissue sarcoma before age 21 years between January
1, 1970 and December 31, 1986 at one of participating centers.

Expanded cohort:

- Five-year survival following diagnosis of leukemia, lymphoma, CNS tumor, bone tumor,
kidney tumor, neuroblastoma, or rhabdomyosarcoma before age 21 years between January
1, 1987 and December 31, 1999 at one of participating centers.

- English- or Spanish-speaking and living in the U.S. or Canada at the time of
diagnosis.

Exclusion Criteria:

- Diagnosis of non-malignant tumors (i.e., Langerhans cell histiocytosis, meningioma,
craniopharyngioma, etc.) treated with radiation and/or chemotherapy.

- Non-English speaking or residence outside the US or Canada.

Sibling Controls:

- For comparison purposes, a group of sibling controls will be identified to represent a
stratified random sample based on the distribution of survivors with regard to cancer
diagnosis, age, sex, race, and geographic location.