Post Kidney Transplant Nocturnal Hypertension Prevalence and Management Study
| Status: | Recruiting |
|---|---|
| Conditions: | High Blood Pressure (Hypertension) |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - 70 |
| Updated: | 5/27/2013 |
| Start Date: | April 2010 |
| Contact: | Rajiv Vij, MD MPH |
| Email: | rvij@nshs.edu |
| Phone: | 516-465-8200 |
Hypertension (HTN) affects up to 75% of kidney transplant recipients and is associated with
premature death. Nocturnal HTN is a common complication of ongoing essential HTN or a
secondary cause of HTN. Both the non dipping of systolic blood pressure (SBP) at night time
and the reverse dipping is associated with increased target organ damage and adverse
cardiovascular outcomes and possibly allograft survival. Treatment of Nocturnal HTN is
critical. Chronotherapy has been shown to be effective in halting progression in patients
with diabetic nephropathy and chronic kidney disease. There is not enough data on
prevalence and management of nocturnal HTN in transplant patients, which is the object of
this study.
Inclusion Criteria:
1. Renal transplant more than 1 year ago and not on dialysis.
2. Age between 18 years to 70 years.
3. Known history of HTN on one or more anti-hypertensive medication.
4. Stable anti-hypertensive regimen for past 2 months
5. One of the anti-hypertensive regimen must include an ACE inhibitor, or an angiotensin
receptor blocker, calcium channel blocker, alpha or beta blocker.
6. Stable immunosuppressive regimen with no dose changes in past 3 months.
7. No hospitalizations for previous 2 months
Exclusion Criteria:
1. Inability to consent
2. History of falls
3. Presence of AVF or AVG in both the arms
4. Inability to follow up in renal transplant clinic.
5. History of Atrial fibrillation.
6. Pregnant Women
7. Parkinson's Disease
8. Severe orthostatic Hypotension
9. Severe autonomic dysfunction
10. History of other transplanted organs
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