Acetaminophen to Prevent Ischemic Oxidative Reperfusion Injury During Percutaneous Coronary Intervention for Acute Myocardial Infarction

Inclusion Criteria:

- Patients presenting with STEMI

Exclusion Criteria:

- Duration of symptoms > 12 hours

- Suspected LM or proximal LAD occlusion (based on EKG interpretation)

- Hemodynamic instability

- Acetaminophen use in prior 24 hours

- Use of dipyridamole, or Aggrenox, a formulation of aspirin and extended-release
dipyridamole, within 48 hours

- Current use of the following medications: phenytoin, valproic acid, phenobarbital,
topiramate, rifampin, carbamazepine, cyclophosphamide, ritonavir, efavirenz, St.
John's Wort

- Chronic heavy alcohol use

- Chronic liver disease (other than non-alcoholic fatty liver infiltration)

- Severe valvular heart disease

- Stroke in the past 60 days

- Active major bleeding

- Major surgery in the past 30 days

- Ongoing treatment for active malignancy

- Life expectancy less than 12 months as determined by the patient's attending
physician

- Pregnancy

- asthma or severe COPD

- active wheezing on presentation

- allergy or prior adverse reaction to adenosine