Magnetic Resonance Imaging (MRI) and Decline of Aging Aviator Performance

We expect that MRI and MRSI techniques will be a useful adjunct in research efforts to
understand individual differences in performance of a complex attention-demanding task, such
as flying a plane or driving a car. Other predictors of change in performance of a complex
task may include simple tests of processing speed and working memory, past training and
recent practice of the task, and genetic risk factors for degenerative brain disease. In
this project, we will examine whether baseline MR measures are as useful as longitudinal MR
measures in predicting amount of change over time in task performance.

This research is part of a long-term effort to achieve earlier identification of individuals
at risk of decline and ultimately minimize loss of function.

Inclusion Criteria:

- Subjects will be included if they have participated in the protocol "Age-Related
Longitudinal Changes in Aviator Performance" and agree to participate in this
protocol.

Exclusion Criteria:

- Subjects will be excluded if they currently have a major neurological disease,
unstable/untreated medical disease (such as untreated hypertension).

- In consideration of the magnetic fields in which subjects will be placed for the MR
scanning, we will also exclude subjects who are unable to safely and comfortably
complete the scanning session. This includes individuals who are wearing any metal
prosthesis or who have cardiac pacemakers or any other nonremovable metal objects.

- Subjects reporting a history of severe claustrophobia or poorly controlled back pain
will be excluded because it is unlikely they could comfortably remain still in the
MRI scanner for the duration of the scan.

- In addition, subjects who do not fit in the apparatus will also be excluded.