Carotid Atherosclerotic Plaque Study
| Status: | Completed |
|---|---|
| Conditions: | Peripheral Vascular Disease, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 11/18/2012 |
| Start Date: | November 2001 |
| End Date: | December 2010 |
| Contact: | Pam Winne |
| Email: | pkw@clinicaltrials.wisc.edu |
First, to establish a comparison of the pathophysiology of carotid atherosclerosis and the
genetic and environmental variables that cause those plaques to become symptomatic. Second,
to differentiate between vulnerable plaque and other types of plaque using ultrasound
elastography, MRI data, trans-cranial doppler along with RF analysis of back-scattered
ultrasonic echoes.
This is a multi-investigator study based on the pathophysiology of carotid atherosclerosis
and the variables that cause certain plaques to become symptomatic.Patients enrolled in this
study will be those patients undergoing a carotid endarterectomy. This will include both
symptomatic and asymptomatic patients, and there are a variety of atherosclerotic risk
factors representing this patient population.Patients may or may not have had strokes or
transient ischemic attacks (TIAs).Pre-operatively patients will be reviewed for their
medical history and atherosclerotic risk factors. Plaque removed during routine carotid
endarterectomy will be examined for study purposes.
Inclusion Criteria:
- Male and Female patients aged 18-80 presenting for carotid endarterectomy
Exclusion Criteria:
- Patients not felt suitable for carotid endarterectomy and those with impaired
decision-making capacity
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