A Study Of Combined C- MET Inhibitor And PAN-HER Inhibitor (PF-02341066 And PF-00299804) In Patients With Non- Small Cell Lung Cancer
| Status: | Completed |
|---|---|
| Conditions: | Lung Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | August 2010 |
| End Date: | February 2014 |
A Phase 1, Open-label, Dose Escalation Study To Evaluate Safety, Pharmacokinetics And Pharmacodynamics Of Combined Oral C-met/Alk Inhibitor (Pf-02341066) And Pan-her Inhibitor (Pf-00299804) In Patients With Advanced Non-small Cell Lung Cancer
Lung cancer tumors become resistant to the first generation epidermal growth factor receptor
(EGFR) inhibitors erlotinib or gefitinib by changing and increasing the activity of two cell
signaling pathways: the cMET pathway and the EGFR pathway. Both resistance mechanisms can
occur at the same time, in the same patient and even in the same tumor. This study combines
a second generation EGFR inhibitor and a cMET inhibitor to block both these pathways in
order to overcome resistance and treat this disease.
(EGFR) inhibitors erlotinib or gefitinib by changing and increasing the activity of two cell
signaling pathways: the cMET pathway and the EGFR pathway. Both resistance mechanisms can
occur at the same time, in the same patient and even in the same tumor. This study combines
a second generation EGFR inhibitor and a cMET inhibitor to block both these pathways in
order to overcome resistance and treat this disease.
Inclusion Criteria:
- advanced non small cell lung cancer (dose escalation phase)
- acquired resistance to erlotinib or gefitinib (expansion phase)
- mandatory entrance biopsy (expansion phase)
Exclusion Criteria:
- interstitial lung disease
- unstable brain metastases
- leptomeningeal disease
We found this trial at
9
sites
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Brigham and Women's Hosp Boston’s Brigham and Women’s Hospital (BWH) is an international leader in...
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University of Colorado Hospital, Site Top medical professionals, superior medicine and progressive change make University...
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East Melbourne, Victoria
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