Hypofractionated Radiotherapy for Lung Cancer
| Status: | Completed |
|---|---|
| Conditions: | Lung Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | June 2004 |
| End Date: | December 2012 |
The Use of Helical Tomotherapy to Achieve Dose-per-fraction Escalation in Lung Cancer
The purpose of this trial is to pilot reducing the duration of radiation treatment for lung
cancer patients from 6 to 5 weeks using tomotherapy. Specific patient doses will be based on
tumor volume being treated. Modeling has shown that increased biologically effective dose
(BED) to tumors can be achieved by shortening the radiation delivery schedule and increasing
the dose per fraction. This requires decreasing the total dose to hold lung toxicity
constant at each dose per fraction level. This is a major paradigm shift in the treatment in
this disease and is projected to result in significant improvements in patient outcome as
well as a substantial cost savings.
cancer patients from 6 to 5 weeks using tomotherapy. Specific patient doses will be based on
tumor volume being treated. Modeling has shown that increased biologically effective dose
(BED) to tumors can be achieved by shortening the radiation delivery schedule and increasing
the dose per fraction. This requires decreasing the total dose to hold lung toxicity
constant at each dose per fraction level. This is a major paradigm shift in the treatment in
this disease and is projected to result in significant improvements in patient outcome as
well as a substantial cost savings.
Inclusion Criteria:
- Thoracic neoplasm requiring at lest 60 Gy conventional radiotherapy
Exclusion Criteria:
- Prior bleomycin or gemcitabine chemotherapy
- Prior thoracic radiotherapy
We found this trial at
1
site
600 Highland Ave
Madison, Wisconsin 53792
Madison, Wisconsin 53792
(608) 263-6400
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