Mucopolysaccharidosis (MPS) VI Clinical Surveillance Program (CSP)

Inclusion Criteria

All patients must meet the following criteria to qualify for enrollment in the CSP:

- Patient or patient's parent or legal guardian, if child is under 18 year old or is
unable to consent, has provided a signed Patient Information and Authorization Form.

- Patient has laboratory results confirming a diagnosis of MPS VI disease based on
detection of deficient ARSB activity (on fibroblasts, leucocytes or dried blood
spots)and/or abnormality on the ARSB gene.

- Patient is willing to undergo general assessments to establish baseline data or
permits physician to enter assessment data recorded prior to CSP entry if available in
the patient's medical records. General assessments include: urinary GAG level, urinary
protein level, serum sample for antibody levels, height, weight, and patient history.