Mindfulness-Based Cognitive Behavior Therapy for Bipolar Disorder

We will conduct a randomized controlled trial of group MBCT (n=30) vs. SP (n=30) and compare
the benefits and durability of MBCT vs. SP for decreasing symptoms in DSM-IV bipolar
individuals over a 12-week period adjunctive to mood stabilizing medications coupled with
individual-therapy sessions. We will also conduct follow-up assessments at 3, 6, 9, and 12
months after the active phase of the study. Subjects in the MBCT group will receive group
therapy sessions of standardized yoga-meditation based exercises enhanced by psychoeducation
and relapse prevention for bipolar disorder. Subjects in the SP group will receive support
for coping with the symptoms of bipolar disorder, as well as psychoeducation about bipolar
disorder. The focus of SP is on reflecting and expressing feelings about current life
issues. Patients are supported and comforted when coping with difficult situations,
depression, mood swings, or anger. We will assess mood, cognitive and psychosocial
functioning before and after treatment for participants in both groups. Finally, we will
investigate the functional neuroanatomy associated with memory impairment, attention, and
mindful breathing in subjects with bipolar disorder as a predictor of treatment response
using functional Magnetic Resonance Imaging (fMRI).