Sugar-replacement Sweeteners, Taste Perception, and Blood Sugar Control



Status:Completed
Conditions:Obesity Weight Loss
Therapuetic Areas:Endocrinology
Healthy:No
Age Range:Any
Updated:10/21/2012
Start Date:May 2010
End Date:September 2012
Contact:Emily Jenkerson, B.A.
Email:jenkersone@dom.wustl.edu
Phone:314-362-1000

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Trial Summary
Trial Overview
Inclusion Criteria

Regulation of Incretin Release by Non-nutritive Sweeteners in Humans


Several sugar-replacement sweeteners are currently on the market, including saccharine (ex.
Sweet'N Low), aspartame (ex. Equal), and sucralose (ex. Splenda). The purpose of this study
is to examine wether non caloric sweeteners affects how well the body works to control blood
sugar. The study includes detailed blood sugar testing after drinking liquids that may
contain sucralose. The investigators hypothesize that drinking liquids with sucralose will
effect the amounts of specific appetite-affecting substances naturally produced by the body.


Inclusion Criteria:

- body mass index (BMI) over 30.

Exclusion Criteria:

- smoking or smoked within last six months

- pregnant or breastfeeding

- have malabsorptive syndromes

- intestinal inflammatory disease

- diabetes

- liver or kidney disease

- fructose intolerance

- consuming more than one can of diet beverage or one spoonful of non-nutritive
sweeteners (e.g. sucralose, aspartame, or saccharine) a week.

- taking any medication that might affect metabolism or taste.
We found this trial at
1
site
Washington University School of Medicine
660 S Euclid Ave
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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Saint Louis, MO
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