A Study Evaluating IPI-926 in Combination With Gemcitabine in Patients With Metastatic Pancreatic Cancer
| Status: | Archived |
|---|---|
| Conditions: | Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | April 2010 |
| End Date: | March 2012 |
A Phase 1b/2 Study Evaluating IPI-926 in Combination With Gemcitabine in Patients With Metastatic Pancreatic Cancer
Study IPI-926-03 is a Phase 1b/2 clinical trial to evaluate IPI 926 in combination with
gemcitabine in patients with previously untreated metastatic pancreatic cancer. Phase 1b is
designed as a dose escalation study. Once the maximum tolerated dose of IPI-926 in
combination with gemcitabine is established in the Phase 1b portion of the study, the Phase
2 portion will commence.
Phase 2 is designed as a randomized, double-blind (investigator/patient), placebo-controlled
study. There is no cross-over option for patients in either arm of the Phase 2 (i.e., there
is no option for patients receiving placebo to cross-over to IPI-926).
IPI 926 is an inhibitor of the Hedgehog Pathway. IPI-926 in combination with gemcitabine
may improve therapeutic outcomes in patients with pancreatic cancer. Infinity is conducting
a Phase 1b/2 clinical trial to evaluate the safety and efficacy of IPI-926 in combination
with gemcitabine in patients with previously untreated metastatic pancreatic cancer.
We found this trial at
6
sites
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13001 E. 17th Pl.
Aurora, Colorado 80045
Aurora, Colorado 80045
303-724-5000
University of Colorado Cancer Center - Anschutz Cancer Pavilion The University of Colorado Denver |...
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Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
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