FAME II - Fractional Flow Reserve (FFR) Guided Percutaneous Coronary Intervention (PCI) Plus Optimal Medical Treatment (OMT) Verses OMT

Prospective, multi-center, multi-national, multi-continental, randomized clinical trial.

Inclusion Criteria:

1. Patients with

- stable angina or,

- stabilized angina pectoris or,

- atypical chest pain or no chest pain but with documented silent ischemia

2. at least one stenosis is present of at least 50% in one major native epicardial
coronary artery and supplying viable myocardium

3. Eligible for PCI

4. Signed written informed consent

Exclusion Criteria:

1. Patients in whom the preferred treatment is CABG

2. Patients with left main coronary artery disease requiring revascularization

3. Patients with a recent STEMI or Non-STEMI

4. Prior CABG

5. Contra-indication to dual antiplatelet therapy

6. LVEF < 30%

7. Severe LV hypertrophy

8. Planned need for concomitant cardiac surgery

9. Extremely tortuous or calcified coronary arteries precluding FFR measurements

10. A life expectancy of less than 2 years

11. Age under 21