Effect of Glutamine Supplemented Nutrition Support on Protein and Glutamine Metabolism in Burns
| Status: | Completed |
|---|---|
| Conditions: | Other Indications, Hospital |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/2/2016 |
| Start Date: | August 1997 |
| End Date: | January 2010 |
| Contact: | Mary-Liz C Bilodeau, MS |
| Email: | mbilodeau@partners.org |
| Phone: | 617-726-8766 |
Study on the Effect of Glutamine Supplemented Nutrition Support on Protein and Glutamine Metabolism in Severely Burned Patients
The Total Parenteral Nutrition (TPN)received as part of your routine burn care has optimal
levels of protein and sugar, however the best mixture of amino acids for a patient with burn
wounds is not yet known. Amino acids occur naturally in the body and the food we eat. The
body combines amino acids to make protein. It uses the proteins to do things such as heal
wounds, fight infection, and provide energy. We are studying if the body's use of protein is
increased after receiving TPN containing the amino acid called glutamine. We hope to learn
the best composition of TPN so that the body can more efficiently repair wounded tissues and
recover earlier from an acute burn injury.
levels of protein and sugar, however the best mixture of amino acids for a patient with burn
wounds is not yet known. Amino acids occur naturally in the body and the food we eat. The
body combines amino acids to make protein. It uses the proteins to do things such as heal
wounds, fight infection, and provide energy. We are studying if the body's use of protein is
increased after receiving TPN containing the amino acid called glutamine. We hope to learn
the best composition of TPN so that the body can more efficiently repair wounded tissues and
recover earlier from an acute burn injury.
Human and animal studies have demonstrated that glutamine catabolism exceeds glutamine
synthesis in burn patients, resulting in a glutamine-depleted status, which compromises
liver function, including glutathione status, proline and arginine homeostasis and whole
body protein balance (1). The purpose of this study is to directly quantify glutamine /
glutamate kinetics in relation to glutamine / glutamate disposal and whole body amino acid
balance, by using stable isotope tracers [1-13C, 15N]leucine and [15N2]urea.
We hypothesize that the enrichment of amino acid mixtures with glutamine will attenuate
overall body nitrogen catabolism and better maintain proline and arginine homeostasis.
The purpose of this study it to 1) investigate the effect of glutamine supplemented total
parenteral nutrition (TPN) on whole body metabolic and disposal rate of glutamine, and its
rate of de novo synthesis in severely burned patients and 2)explore the impact of glutamine
supplementation on whole body protein turnover, studied with L-[1-13C, 15N}-leucine, and on
the metabolic homeostasis of urea cycle.
synthesis in burn patients, resulting in a glutamine-depleted status, which compromises
liver function, including glutathione status, proline and arginine homeostasis and whole
body protein balance (1). The purpose of this study is to directly quantify glutamine /
glutamate kinetics in relation to glutamine / glutamate disposal and whole body amino acid
balance, by using stable isotope tracers [1-13C, 15N]leucine and [15N2]urea.
We hypothesize that the enrichment of amino acid mixtures with glutamine will attenuate
overall body nitrogen catabolism and better maintain proline and arginine homeostasis.
The purpose of this study it to 1) investigate the effect of glutamine supplemented total
parenteral nutrition (TPN) on whole body metabolic and disposal rate of glutamine, and its
rate of de novo synthesis in severely burned patients and 2)explore the impact of glutamine
supplementation on whole body protein turnover, studied with L-[1-13C, 15N}-leucine, and on
the metabolic homeostasis of urea cycle.
Inclusion Criteria:
Burn patients being treated at MGH Burn Unit with one or more of the following criteria:
1) >=5% TBSA; 2) inhalation injury; or 3) resting energy expenditure (REE) of >15% of the
predicted Basal Metabolic Rate using the Harris-Benedict equation.
Must be receiving total parenteral nutrition in the course of their treatment.
Exclusion Criteria:
Patients with thyroid disease. Patients who are not hemodynamically stable or show
unstable vital signs Patients at the stage of major organ failure, e.g. renal and/or liver
failure.
We found this trial at
1
site
Click here to add this to my saved trials
