Effects of Dronedarone on Atrial Fibrillation Burden in Subjects With Permanent Pacemakers

The primary Objective of this study is to:

- Evaluate the effects of dronedarone on Atrial Fibrillation (AF) burden (percent of time in
which a subject is in AF) based on electrogram (EGM) data in subjects with a permanent
pacemaker

The secondary Objectives of this study are to:

- Evaluate the effects on AF pattern characteristics: number of episodes, duration, and
ventricular rate during AF

- Evaluate the effects on subject-perceived AF burden and symptom severity as reported by
subjects using the Atrial Fibrillation Severity Scale (AFSS)

- Evaluate the relationships between AF burden and subject-perceived AF burden as well as
AF symptom severity as reported on the AFSS

- Evaluate the incidence of electrical cardioversion (or overdrive pacing) during
treatment

- Evaluate the incidence of persistent AF during treatment

- Evaluate the safety of dronedarone