Impact of Exenatide on Sleep in Type 2 Diabetes
| Status: | Completed |
|---|---|
| Conditions: | Insomnia Sleep Studies, Diabetes |
| Therapuetic Areas: | Endocrinology, Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 9/14/2018 |
| Start Date: | June 1, 2010 |
| End Date: | September 1, 2016 |
Impact of Exenatide on Sleep and Circadian Function in Type 2 Diabetes: A Pilot Study
The investigators propose a pilot study to test the novel hypothesis that Exenatide treatment
in patients with type 2 diabetes results in improved sleep duration and quality and to
explore the relationship between improvements in sleep and measures of metabolic and
circadian function. This project would be the first to probe the relationship between
incretin hormone regulation, duration and intensity of sleep, glucose tolerance and circadian
dysfunction in diabetic patients.
in patients with type 2 diabetes results in improved sleep duration and quality and to
explore the relationship between improvements in sleep and measures of metabolic and
circadian function. This project would be the first to probe the relationship between
incretin hormone regulation, duration and intensity of sleep, glucose tolerance and circadian
dysfunction in diabetic patients.
Inclusion Criteria:
- Patients with a diagnosis of T2DM based on physician documentation according to
established guidelines will be eligible.
Exclusion Criteria:
- Patients with unstable cardiac, neurological or psychiatric disease
- Women who are pregnant or report trying to get pregnant will be excluded.
- Patients treated for obstructive sleep apnea (OSA) will be excluded.
- Patients with established OSA will be included only if they have declined treatment of
OSA.
- Patients with morbid obesity (BMI ≥ 40 gk/m2)
- Patients on insulin
- Patients already taking an incretin-based drug will not be included
- Patients with renal disease (creatinine clearance <30 ml/min), gastroparesis and
history of pancreatitis will also be excluded based on known possible adverse
medication side effects.
- Patients taking an insulin secretagogue will be excluded.
- Patients with Hemoglobin A1c values greater than or equal to 10 will be excluded.
We found this trial at
2
sites
University of Chicago One of the world's premier academic and research institutions, the University of...
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University of Chicago One of the world's premier academic and research institutions, the University of...
Click here to add this to my saved trials