Pediatric Catheter-related Thrombosis Imaging Study

Inclusion Criteria:

- Functioning central venous catheter in the upper or lower venous system

- Cohort A: Asymptomatic patients having placement of a new central venous catheter in
the last 40±20 days

- Cohort B: Subjects who have experienced symptoms for a CVC-related DVT with a CVC in
place or subjects who have been incidentally identified by radiographic imaging
(imaging modalities to diagnose an incidental CVC-related DVT may include, but is not
exclusive of Echocardiogram, CT scan, MRI, or Ultrasound) performed for other
clinical reasons, as having a CVC-related DVT in the veins where the current catheter
is placed

- Males and females from full-term newborns to < 18 years

Exclusion Criteria:

- For Cohort A subjects only, present therapeutic dosing of a systematic anticoagulant,
systemic thromboprophylaxis or antiplatelet therapy. Local thromboprophylaxis
[flushes, low dose infusions of heparin of up to 5 u/kg/hr or locks with heparin,
urokinase, t-plasminogen activator] according to standard-of-care at the respective
center will be allowed

- Patients unable to undergo contrast enhanced magnetic resonance imaging

- Renal function < 50% of normal for age and size