Assessing Fertility Potential in Female Cancer Survivors
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Cancer, Cancer, Women's Studies |
| Therapuetic Areas: | Oncology, Reproductive |
| Healthy: | No |
| Age Range: | 11 - 50 |
| Updated: | 6/27/2018 |
| Start Date: | March 2006 |
| End Date: | June 30, 2021 |
Hypothesis: Girls and women exposed to chemotherapy and/or radiation therapy experience
endocrine changes more similar to women in their late reproductive years than to same-age
peers. These changes will be more dramatic in women who receive high dose therapy compared to
women who receive low dose therapy.
At annual visits over 3-5 years, a combination of physical exam, medical history, menstrual
diary keeping, pelvic ultrasound and blood hormones tests will be used to measure "ovarian
reserve" , that is the number and quality of the eggs that remain in the ovaries. The study
will also try to learn if those who received higher doses of certain chemotherapies are more
likely to have changes in these tests sooner than those women who received smaller doses of
these same drugs. Additionally a DNA (deoxyribonucleic acid) sample will be collected to look
for gene variations that may predict susceptibility to ovarian damage from cancer treatments.
Information learned from this study may help researchers to develop guidelines to identify
problems with a female cancer survivor's ovaries before irregular menses or other symptoms of
ovarian failure occur.
endocrine changes more similar to women in their late reproductive years than to same-age
peers. These changes will be more dramatic in women who receive high dose therapy compared to
women who receive low dose therapy.
At annual visits over 3-5 years, a combination of physical exam, medical history, menstrual
diary keeping, pelvic ultrasound and blood hormones tests will be used to measure "ovarian
reserve" , that is the number and quality of the eggs that remain in the ovaries. The study
will also try to learn if those who received higher doses of certain chemotherapies are more
likely to have changes in these tests sooner than those women who received smaller doses of
these same drugs. Additionally a DNA (deoxyribonucleic acid) sample will be collected to look
for gene variations that may predict susceptibility to ovarian damage from cancer treatments.
Information learned from this study may help researchers to develop guidelines to identify
problems with a female cancer survivor's ovaries before irregular menses or other symptoms of
ovarian failure occur.
Up to 400 females will participate in this study in one of three cohorts:
- 150 females ages 11-35, with history of exposure to alkylating agent chemotherapy and/or
radiation therapy
- 150 Unexposed peers, ages 11-35, never exposed to chemotherapy or radiation therapy
- 100 Unexposed females, ages 40-50 never exposed to chemotherapy or radiation therapy
- 150 females ages 11-35, with history of exposure to alkylating agent chemotherapy and/or
radiation therapy
- 150 Unexposed peers, ages 11-35, never exposed to chemotherapy or radiation therapy
- 100 Unexposed females, ages 40-50 never exposed to chemotherapy or radiation therapy
Inclusion Criteria for cancer survivors:
- Previous treatment with chemotherapy and/or radiation therapy for either cancer or
another illness.
- Age between 11-35 years.
- Post-menarchal.
- Presence of a uterus and at least one ovary.
- Ability and willingness to comply with study protocol.
- Have given written informed consent, prior to any study-related procedure, not part of
normal medical care, with the understanding that consent may be withdrawn by the
patient at any time without prejudice to their future medical care.
Inclusion Criteria for controls:
- Healthy females who have never been treated for cancer.
- Age between 11-35 and 40-50 years.
- Post-menarchal with regular cyclic menses (every 21-35 days)
- Presence of a uterus and at least 1 ovary.
- Ability and willingness to comply with study protocol.
- Have given written informed concent, prior to any study-related procedure, not part of
normal medical care, with the understanding that consent may be withdrawn by the
patient at any time without prejudice to their future medical care.
Exclusion Criteria:
- Current pregnancy.
- Use of hormonal contraception or use of hormone replacement therapy within the
previous 4 weeks.
- Lactation within the previous 3 months.
- Chronic illness that would limit ability of participant to comply with study protocol.
- Any known medical condition, other than cancer, which in the judgement of the
investigator is known to be associated with premature ovarian failure (such as
Turner's Syndrome or Fragile X) or ovulatory dysfunction (such as thyroid disease,
adrenal dysfunction, Cushing's syndrome, hyperprolactinemia, and polycystic ovarian
syndrome).
- For controls, a history of infertility.
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