A Pilot Study to Evaluate the Use of C1 Esterase Inhibitor (Human) in Patients With Acute Antibody-Mediated Rejection

Inclusion Criteria include:

- ≥18 years of age.

- Weigh ≥50 kg.

- Donor specific antibody identified.

Exclusion Criteria include:

- Any surgical or medical condition that could interfere with the administration of
study drug or interpretation of study results.

- History of allergic reaction to C1 Esterase Inhibitor or other blood products.

- Participation in the active dosing phase of any other investigational drug study
within 30 days prior to dosing with study drug.

- Pregnancy or lactation.

- Receipt of any experimental agents for AMR within 1 month prior to the first dose of
study drug.

- Any infection that causes hemodynamic compromise.

- History of bleeding or clotting abnormality.