Dose Ranging Study Evaluating the Efficacy and Safety of GSK2190915 Administered Once Daily

Inclusion Criteria:

- Type of Subject: Outpatient

- Age: ≥12 years of age

- Gender: Eligible Female (females of childbearing potential must commit to consistent
and correct use of an acceptable method of birth control)

- Asthma Diagnosis: As defined by NIH

- Severity of Disease: FEV1 50-85% predicted AND in current and former smokers a post
salbutamol/albuterol ratio >0.70

- Reversibility: ≥12% and ≥200mL in FEV1 within 30 ±15 minutes following
salbutamol/albuterol

- Current anti-asthma therapy: Using short-acting beta-agonist (SABA) for ≥3 months

- Tobacco use: Non-smoker /former smoker with ≤10 pack years or current smoker with ≤10
pack years

- QTC: QTc(F)<450msec or QTc(F)<480 for subjects with Bundle Branch Block

- Liver function: Normal liver function

- Informed Consent

Exclusion Criteria:

- History of Life-threatening asthma: Within previous 5 years

- Asthma Exacerbation: Requiring OCS within 3 months or hospitalisation within 6 months

- Respiratory Infection: Not resolved within the 4 weeks before V1 AND led to a change
in asthma management OR treatment with antibiotics OR is expected to affect the
subject's asthma status or ability to participate

- Corticosteroid Use: ICS used within 6 weeks or OCS/depot corticosteroids within 12
weeks

- OATP1B1 substrates: OATP1B1 substrates (e.g. statins, rifampicin,
bromosulphophthalein, benzylpenicillin, methotrexate) within 4 weeks

- Immunosuppressive medications: Either using or required during the study

- Liver disease: Current or chronic history

- Concurrent disease/abnormalities: Clinically significant uncontrolled disease

- Investigational medications: Participation in a study or used investigational drug
within 30 days

- Drug allergy: β-agonists, corticosteroids, constituents of inhalers

- Milk Protein Allergy: History of severe milk protein allergy

- Compliance: Factors likely to impair compliance either with regards to study
medication, procedures or attendance

- Unable or unwilling to follow instructions: Procedures, dosing directions, e-diaries
or pMDIs

- History of alcohol or drug abuse: Likely to interfere with the study

- Affiliation with Investigator's Site: Relative or employee