Herbal Lollipops on Oral Bacterial Levels and DMFT/Dmft Scores of Children With Asthma Using Inhalers

This study is entitled, "Effects of herbal lollipops on Streptococcus Mutans levels and the
dental caries experience of children with asthma taking beta2-adrenergic drugs." In this
study, forty-five (45) children between the ages of four (4) and sixteen (16) with bronchial
asthma taking a beta2-adrenergic agonist drug at least once a week will participate in a six
(6) month regimen of herbal lollipops as adjunctive oral hygiene therapy. The objective of
this study is to determine how effective the six-month regimen of herbal lollipops is at
controlling the Streptococcus Mutans levels and the caries process in the study group.
Whether or not a case can be made for including herbal lollipops in standard oral hygiene
protocol for children with asthma will also be a goal of this study. Relevant data will be
collected using the following method. The subjects of this study will be provided with and
instructed to dissolve two (2) herbal lollipops by mouth per day for the first ten (10) days
of the study and again for ten (10) days three (3) months into the study. Each subject will
receive a total of forty (40) lollipops for the study. The study group will be matched with a
control group of forty-five (45) children who also have asthma and who take beta2-adrenergic
agonist drugs as needed for symptoms. The children in the control group will be given placebo
lollipops and will be instructed to use them in the manner described above. All ninety (90)
subjects will be drawn from the collective patient pools of the UNMC College of Dentistry in
Lincoln, NE, and the UNMC Pediatric Dentistry and UNMC Pediatrics Clinics in Omaha, NE. Oral
hygiene instructions will be given to all participating subjects at the onset of the study.
Entrance Streptococcus mutans levels and decayed, missing and filled teeth scores (DMFT/dmft)
will be determined on the subjects and changes over the six (6) month study will be compared
and evaluated. If some stabilization or improvement in the Streptococcus mutans levels and/or
dental caries experience in the study group is shown, such promising results will allow for
implementation of longer-term studies. The significance of this study is that adjunctive oral
hygiene therapy that employs herbal lollipops may prove to help children who suffer from
bronchial asthma lower their dental caries risks and have healthier oral environments
unburdened by the effects of their medication and condition.

Inclusion Criteria:

- Must have a medical diagnosis of asthma and must use a beta2-adrenergic agonist
inhaler or nebulizer for their symptoms as needed.

- Must not have any other serious medical conditions that require taking another
illness-related medication that may cloud the study results. (i.e. medications that
have been shown to have anti-sialogogue effects.

- Must not have a history of severe early childhood caries (SECC) or "baby bottle tooth
decay."

- Must fall within the age range of four (4) to sixteen (16) years old.

- Must be available to return for data collection during six (6) months of participation
in the experiment.

Exclusion Criteria:

- Children who do not fall within all the aforementioned inclusion criteria will not be
considered for participation in this study.