Attenuating Ischemia Reperfusion Injury After Living Donor Renal Transplantation



Status:Completed
Conditions:Peripheral Vascular Disease, Renal Impairment / Chronic Kidney Disease, Cardiology
Therapuetic Areas:Cardiology / Vascular Diseases, Nephrology / Urology
Healthy:No
Age Range:Any
Updated:11/18/2012
Start Date:June 2010
End Date:December 2012

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Trial Summary
Trial Overview
Inclusion Criteria

Patients undergoing living donor renal transplant will be asked to participate to determine
whether pre-operative dosing of immunosuppressive medication, and the donor organ receiving
an additional dose of antibody induction therapy helps to alleviate potential damage to the
transplanted organ post-transplant. A number of lab tests will be done post-transplant to
determine how well the kidney is functioning.


Inclusion Criteria:

1. Must be able to provide written informed consent.

2. All recipients of a kidney from a living donor only, either a de novo transplant, or
re-transplant

3. All patients evaluated and listed with the United Network for Organ Sharing (UNOS)
who are eligible to receive a kidney transplant under GUH's standard protocol.

4. Patients between 18-80 years of age

Exclusion Criteria:

1. Recipients of multi-organ transplant

2. Patients with known allergies of hypersensitivities to any of the drugs used in this
protocol

3. Recipients of kidneys from a deceased donor

4. Recipients who are co-infected with Hepatitis B, Hepatitis C or HIV

5. Women who are pregnant

6. Women of child-bearing potential, defined as all women physiologically capable of
becoming pregnant, including women whose career, lifestyle or sexual orientation
precludes intercourse with a male partner unless they agree to avoid pregnancy
throughout the duration of the trial and for 3 months following the trial.
We found this trial at
1
site
Georgetown University Hospital
3800 Reservoir Rd NW
Washington, District of Columbia 20007
(202) 444-2000
Georgetown University Hospital MedStar Georgetown University Hospital is a not-for-profit, acute-care teaching and research hospital...
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