Studies of Avian Influenza Transmission to Humans in Egypt
| Status: | Archived |
|---|---|
| Conditions: | Influenza |
| Therapuetic Areas: | Immunology / Infectious Diseases |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | June 2010 |
| End Date: | April 2014 |
Prospective Studies of Avian Influenza Transmission to Humans in Egypt
The main focus of the study is :
- To estimate seroprevalence of AI in poultry-exposed and non-exposed human populations.
- To estimate the incidence of AI in poultry-exposed and non-exposed human populations.
- To investigate risk factors associated with AI infections in occupationally-exposed
poultry workers.
The secondary objectives of the study :
- To investigate patterns in transmission of AI to household contacts of AI clinical
cases
- To isolate AI viruses from acute cases
- To monitor the pathogenicity and disease severity of AI viruses causing human
infections
This 4-year prospective cohort study to compare individuals with occupational exposure to
poultry with non-poultry exposed adult controls for evidence of incident and previous
infections with AI viruses.At the start of this study, study staff will obtain informed
consent,and a blood sample will be obtained from study volunteers to establish baseline
levels of antibodies against avian influenza types H4-H12. Subjects will be interviewed
regarding their exposures, medical history,and behaviors using a close-ended questionnaire
specifically tailored for this study. After one year, study subjects will be interviewed
again to note any changes in exposure variables. At this time, another blood sample will be
obtained and tested for any changes in antibodies' levels. The same procedures will be
repeated at the final visit after another year. Exposed individuals will be selected from
rural areas where poultry is commonly raised. Non-exposed controls will be selected from
urban neighborhoods in Cairo.
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