Effect of Menstrual Cycle on Central Nervous System (CNS) Processing of Gut Stimuli in Irritable Bowel Syndrome (IBS) and Control
| Status: | Terminated |
|---|---|
| Conditions: | Irritable Bowel Syndrome (IBS) |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | 18 - 40 |
| Updated: | 12/1/2017 |
| Start Date: | March 1999 |
| End Date: | February 2015 |
Effect of Menstrual Cycle and Irritable Bowel Syndrome on the Central Nervous System Processing of Gut Stimuli
The hypothesis of the study is that women perceive intestinal stimulation (rectal balloon
distention) differently in different phases of the menstrual cycle, i.e there is an effect of
hormones on the sensory pathway, and that this difference is reflected in the Central Nervous
System processing of this signal. We also hypothesize that there is a difference in
perception between control subjects and subjects with the irritable bowel syndrome.
distention) differently in different phases of the menstrual cycle, i.e there is an effect of
hormones on the sensory pathway, and that this difference is reflected in the Central Nervous
System processing of this signal. We also hypothesize that there is a difference in
perception between control subjects and subjects with the irritable bowel syndrome.
There is discrepancy in the literature concerning the effect of the menstrual cycle on bowel
function and pain syndromes such at irritable bowel syndrome. In addition, recent studies
indicate a difference in the CNS processing of rectal stimulation in normal subjects and
patients with IBS. This study will determine the differences in the perception of rectal
balloon distention in the follicular and luteal phases of the menstrual cycle, in control
subjects with no bowel symptoms and volunteers with IBS, and will compare the CNS processing
of this signal using functional MRI , again in the two phases of the menstrual cycle.
Comparisons: between control subjects without GI symptoms and those with irritable bowel
syndrome.
function and pain syndromes such at irritable bowel syndrome. In addition, recent studies
indicate a difference in the CNS processing of rectal stimulation in normal subjects and
patients with IBS. This study will determine the differences in the perception of rectal
balloon distention in the follicular and luteal phases of the menstrual cycle, in control
subjects with no bowel symptoms and volunteers with IBS, and will compare the CNS processing
of this signal using functional MRI , again in the two phases of the menstrual cycle.
Comparisons: between control subjects without GI symptoms and those with irritable bowel
syndrome.
Inclusion Criteria:
- controls - normal bowel function
- Irritable bowel syndrome - Rome II criteria
- Normal menstrual cycle
Exclusion Criteria:
- irregular menses
- pregnancy
- use of psychotropic medication
- claustrophobia
- metal implants
- metal in eyes
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