Neural Mechanisms in Asthma
| Status: | Completed |
|---|---|
| Conditions: | Asthma |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - 45 |
| Updated: | 4/21/2016 |
| Start Date: | October 2011 |
| End Date: | November 2014 |
Neural Mechanisms by Which Chronic Stress Regulates Inflammation in Asthma
Asthma is a chronic disease that affects nearly 13% of adults in the U.S., causing
substantial impairment that is reflected in the tens of millions of missed days of work, and
doctors' and emergency room visits it leads to annually. Those who have asthma are twice as
likely to develop depression and anxiety, which are associated with more frequent and severe
asthma symptoms, especially in those under chronic stress. The project proposed here seeks
to understand the role of the brain in these associations and to evaluate the neural
mechanisms through which a safe, low-cost intervention, that influences the function of body
via the mind, may diminish the expression of asthma symptoms.
substantial impairment that is reflected in the tens of millions of missed days of work, and
doctors' and emergency room visits it leads to annually. Those who have asthma are twice as
likely to develop depression and anxiety, which are associated with more frequent and severe
asthma symptoms, especially in those under chronic stress. The project proposed here seeks
to understand the role of the brain in these associations and to evaluate the neural
mechanisms through which a safe, low-cost intervention, that influences the function of body
via the mind, may diminish the expression of asthma symptoms.
Inclusion Criteria:
- Asthmatics:
- Physician diagnosed asthma with previous use of asthma medication
- Controls:
- negative skin-prick test to cat dander or house dust mite and have no history of
asthma
- Chronic Stress:
- score 3 or above on any subscale of the UCLA (University of California Los
Angeles) chronic stress interview
No chronic stress:
score 1.5 or below on all subscales of the UCLA chronic stress interview
Exclusion Criteria:
- Individuals with severe asthma, or those whom currently require the use of
corticosteroids
- Individuals with significant medical problems
- Individuals who smoke cigarettes
- Individuals a previous adverse reaction to corticosteroids, a recent (< 1 month)
viral illness, a history of severe asthma or anaphylaxis.
- Breastfeeding women or women who are, suspect they might be or are trying to become
pregnant
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