Periodontal Disease and P. Gingivalis in Rheumatoid Arthritis
| Status: | Completed |
|---|---|
| Conditions: | Arthritis, Healthy Studies, Osteoarthritis (OA), Rheumatoid Arthritis, Dental |
| Therapuetic Areas: | Dental / Maxillofacial Surgery, Rheumatology, Other |
| Healthy: | No |
| Age Range: | 19 - Any |
| Updated: | 5/5/2014 |
| Start Date: | July 2010 |
| End Date: | July 2013 |
| Contact: | Debra A Bergman, MPH |
| Email: | dabergma@unmc.edu |
| Phone: | 402-559-8846 |
Periodontitis (PD) has been postulated to be a risk factor for the onset and progression of
rheumatoid arthritis (RA). Recent reports suggest that infection with Porphyromonas
gingivalis (P. gingivalis), a major oral pathogen in PD, could play a pivotal role in the
development RA. The objective of this study is to examine the relationship of PD and P.
gingivalis infection with the risk and severity of RA.
rheumatoid arthritis (RA). Recent reports suggest that infection with Porphyromonas
gingivalis (P. gingivalis), a major oral pathogen in PD, could play a pivotal role in the
development RA. The objective of this study is to examine the relationship of PD and P.
gingivalis infection with the risk and severity of RA.
In this study, we will examine whether PD and P. gingivalis impact RA risk by enrolling 300
patients with RA and 300 comparator patients with osteoarthritis and comparing results from
comprehensive dental examinations and antibody responses to P. gingivalis. We will examine
whether these associations are modified by the presence of certain genetic risk factors
previously implicated in RA and whether evidence of infection with P. gingivalis precedes RA
onset by examining banked sera from the Department of Defense Serum Repository (DoDSR) and
the Studies of the Etiology of RA (SERA). We also plan to explore whether there are novel
proteins expressed by P. gingivalis that drive autoimmunity in RA and whether immune
responses to these bacterial proteins predict the future development of RA.
patients with RA and 300 comparator patients with osteoarthritis and comparing results from
comprehensive dental examinations and antibody responses to P. gingivalis. We will examine
whether these associations are modified by the presence of certain genetic risk factors
previously implicated in RA and whether evidence of infection with P. gingivalis precedes RA
onset by examining banked sera from the Department of Defense Serum Repository (DoDSR) and
the Studies of the Etiology of RA (SERA). We also plan to explore whether there are novel
proteins expressed by P. gingivalis that drive autoimmunity in RA and whether immune
responses to these bacterial proteins predict the future development of RA.
Inclusion Criteria:
- Age 19 years or older
- Diagnosis of rheumatoid arthritis, osteoarthritis, or healthy control
- Have 9 or more evaluable posterior teeth (out of a total of 28 teeth, excluding third
molars)
- Willing and able to provide informed consent
Exclusion Criteria:
- Received tetracyclines within the last 6 months.
- Need for antibiotic premedication for dental probing.
- Pregnant or breast feeding
We found this trial at
1
site
Click here to add this to my saved trials
