D-cycloserine Adjunctive Treatment for Posttraumatic Stress Disorder (PTSD) in Adolescents
| Status: | Archived |
|---|---|
| Conditions: | Psychiatric |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | June 2010 |
| End Date: | June 2012 |
D-cycloserine Adjunctive Treatment for PTSD in Adolescents
The purpose of this study is to show whether D-cycloserine in combination with cognitive
behavioral therapy (CBT) is more effective than CBT alone to reduce symptoms of
posttraumatic stress disorder (PTSD) in 13-18 year-old children.
While most individuals with PTSD treated with cognitive behavioral therapy (CBT) show
improvement, they still have some enduring symptoms and functional impairment. Accordingly,
there is a need for treatment advances. D-cycloserine (DCS), an antibiotic that has been
used for over 50 years, has also been found to have positive effects on cognition and
anxiety. DCS was found to enhance learning and memory, and also facilitates extinction of
fear reactions. However, DCS only produces an extinction effect when paired with behavioral
training, not when simply given alone. Thus, the medication only needs to be given for
seven doses in this research and youth do not need to take the medication long term. The
research also includes a three-month follow-up.
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