Resveratrol in Type2 Diabetes and Obesity
| Status: | Completed |
|---|---|
| Conditions: | Obesity Weight Loss, Endocrine, Diabetes |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 11/18/2012 |
| Start Date: | December 2008 |
| End Date: | April 2013 |
| Contact: | Cathy Gamel |
| Email: | cgamel@kaleidahealth.org |
| Phone: | 7168874486 |
Effect of Resveratrol on Insulin Resistance and Inflammatory Mediators in Obese and Type 2 Diabetic Subjects
The main objective of this study is to investigate the effect of resveratrol on inflammatory
mediators and insulin resistance at the cellular and molecular level in obese non diabetic
and type 2 diabetic subjects in vivo. This research will investigate the hypothesis that
resveratrol, when given orally to obese and type 2 diabetic subjects induces a decrease in
reactive oxygen species (ROS) generation and the pro-inflammatory transcription factor
nuclear factor-kB (NF-kB) and the inflammatory mediators regulated by it. The hypothesis
that resveratrol suppresses the high fat, high carbohydrate (HFHC) meal induced inflammatory
and oxidative response, will also be investigated. This research will also investigate the
hypothesis that resveratrol intake for 12 weeks improves insulin sensitivity by lowering the
Homeostasis model assessment of insulin resistance (HOMA-IR), an index of insulin resistance
and, that resveratrol intake will cause an increase in incretins.
Inclusion Criteria:
1. 20 years of age and older
2. Healthy Obese subjects with BMI > 30
3. Type 2 Diabetics with BMI > 30
4. Subjects with good peripheral vein.
5. Subjects on statins, ACE inhibitors and thiazolidenediones will be allowed as long as
they are on stable doses of these compounds and the dosage is not changed during the
course of study.
Exclusion Criteria:
1. Subjects on any antioxidant medication
2. Patient on non-steroidal anti-inflammatory drug
3. On any agent with significant antioxidant properties.
4. History of drug or alcohol abuse
5. Any life threatening disease
6. Allergy to peanuts, grapes, wine, mulberries.
7. Pregnant women.
8. Coronary event or procedure (myocardial infarction, unstable angina, coronary artery
bypass surgery or coronary angioplasty) in the previous four weeks.
9. Subjects on anticoagulants.
We found this trial at
1
site
Click here to add this to my saved trials
