Role of Cysteinyl Leukotrienes in the Pathogenesis of Asthma in Obesity
| Status: | Completed |
|---|---|
| Conditions: | Asthma, Obesity Weight Loss |
| Therapuetic Areas: | Endocrinology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 1/26/2018 |
| Start Date: | July 2010 |
| End Date: | May 2013 |
The purpose of this study is to examine whether there are higher levels of cysteinyl
leukotrienes in obese subjects than in non-obese subjects. Cysteinyl leukotrienes are
pro-inflammatory substances that cause asthma by narrowing the airways of the lung. The
investigators want to see if subjects with increased fat stores and therefore increased
leptin, which is a fat-related protein that regulates leukotrienes, have increased levels of
leukotrienes in the blood, lung and urine. The investigators would also like to determine the
relationship between cysteinyl leukotrienes and exhaled nitric oxide levels in asthmatics
with and without obesity. Nitric oxide is anti-inflammatory and suppresses leukotriene
synthesis.
leukotrienes in obese subjects than in non-obese subjects. Cysteinyl leukotrienes are
pro-inflammatory substances that cause asthma by narrowing the airways of the lung. The
investigators want to see if subjects with increased fat stores and therefore increased
leptin, which is a fat-related protein that regulates leukotrienes, have increased levels of
leukotrienes in the blood, lung and urine. The investigators would also like to determine the
relationship between cysteinyl leukotrienes and exhaled nitric oxide levels in asthmatics
with and without obesity. Nitric oxide is anti-inflammatory and suppresses leukotriene
synthesis.
This is a cross-sectional observational study to characterize the association between obese
asthmatics and the inflammatory mediators cysteinyl leukotrienes. Our hypothesis is that
altered adipokine levels in obesity result in augmented cysteinyl leukotriene synthesis that
play a significant role in the pathogenesis of asthma in these subjects.
asthmatics and the inflammatory mediators cysteinyl leukotrienes. Our hypothesis is that
altered adipokine levels in obesity result in augmented cysteinyl leukotriene synthesis that
play a significant role in the pathogenesis of asthma in these subjects.
Inclusion Criteria:
- 18-65 yr old adults with asthma, non-smoking for at least one year
- Healthy non-smoking adults, aged 18-65 without asthma
- Heavy subjects with BMI > 30 kg/m2
- Subjects with normal weight (BMI between 20-25 kg/m2)
- Subject not taking anti-leukotriene therapy (Singulair, Accolate, Zyflo)
Exclusion Criteria:
- No chronic oral steroid use
- No recent history of infection
- No recent history of flare of lung disease
We found this trial at
1
site
500 S State St
Ann Arbor, Michigan 48109
Ann Arbor, Michigan 48109
(734) 764-1817
Principal Investigator: Michael Coffey, MD
Phone: 734-936-9875
University of Michigan The University of Michigan was founded in 1817 as one of the...
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