The Jackson Heart Study of Cardiovascular Disease Among African Americans
| Status: | Active, not recruiting |
|---|---|
| Conditions: | High Blood Pressure (Hypertension), Peripheral Vascular Disease, Cardiology, Neurology |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Neurology |
| Healthy: | No |
| Age Range: | 35 - 84 |
| Updated: | 9/8/2018 |
| Start Date: | September 2000 |
| End Date: | August 2024 |
This is a prospective study of the environmental and genetic factors that influence the
development of cardiovascular disease (CVD) in African American men and women. The cohort is
an expansion of the Jackson, Mississippi site of the Atherosclerosis Risk in Communities
(ARIC) study and is a partnership among two minority institutions (Jackson State University
and Tougaloo College), one majority institution in Jackson, Mississippi (the University of
Mississippi Medical Center), the Mississippi State Department of Health, the National
Institutes of Health (NIH) National Center on Minority Health and Health Disparities (NCMHD),
and the National Heart, Lung, and Blood Institute (NHLBI).
development of cardiovascular disease (CVD) in African American men and women. The cohort is
an expansion of the Jackson, Mississippi site of the Atherosclerosis Risk in Communities
(ARIC) study and is a partnership among two minority institutions (Jackson State University
and Tougaloo College), one majority institution in Jackson, Mississippi (the University of
Mississippi Medical Center), the Mississippi State Department of Health, the National
Institutes of Health (NIH) National Center on Minority Health and Health Disparities (NCMHD),
and the National Heart, Lung, and Blood Institute (NHLBI).
The Jackson Heart Study (JHS) https://www.jacksonheartstudy.org/jhsinfo/, initiated in 1998,
is a longitudinal investigation of genetic and environmental risk factors associated with the
disproportionate burden of cardiovascular disease (CVD) in African-Americans. In addition,
the JHS conducts community education and outreach activities to promote healthy lifestyles
and reduce disease risk burden, undergraduate- and graduate-level research training programs,
and high school science and math enrichment programs to prepare and encourage
underrepresented minority students to pursue biomedical careers.
(www.jacksonheartstudy.org/). The JHS represents an expansion of the Jackson Field Center of
the Atherosclerosis Risk in Communities (ARIC) study (http://www2.cscc.unc.edu/aric/), to
broaden data collection in an African- American population and to increase access to and
participation of African American populations and scientists in biomedical research and
professions. The study recruited 5306 African-American residents living in the Jackson, MS,
metropolitan statistical area (MSA) of Hinds, Madison, and Rankin Counties. Participants were
enrolled from each of 4 recruitment pools: random, 17%; volunteer, 30%; currently enrolled in
the Atherosclerosis Risk in Communities (ARIC) Study, 31% (shared JHS/ARIC cohort); and
secondary family members, 22%. Recruitment was limited to non-institutionalized adult African
Americans 35-84 years old, except in a nested family cohort where those 21 to 34 years of age
were also eligible. The final cohort of participants included 6.59% of all African American
Jackson MSA residents aged 35-84 during the baseline exam (N-76,426, US Census 2000). Among
these, approximately 3,700 gave consent that allows genetic research and deposition of data
into dbGaP. Enrolled JHS participants received three back-to-back clinical examinations (Exam
1, 2000-04; Exam 2, 2005-08; and Exam 3, 2009-13) that have generated extensive longitudinal
data on: traditional and putative CVD risk factors, socioeconomic and sociocultural factors,
and biochemical analytes; and measures of subclinical disease from echocardiography, cardiac
magnetic resonance imaging (MRI), and computed tomography (CT) scans of the heart, aorta, and
abdomen. Stored biological samples have been assayed for putative biochemical risk factors
and stored for future research. DNA has been extracted and lymphocytes cryopreserved for
study of candidate genes, genome-wide scanning, expression, and other -omics investigations.
Participants have been contacted annually to: update information; confirm vital statistics;
document interim medical events, hospitalizations, and functional status; and obtain
additional sociocultural information. Ongoing cohort surveillance includes abstraction of
medical records and death certificates for relevant International Classification of Diseases
(ICD) codes and adjudication of nonfatal events and deaths. The JHS serves as a resource to
the scientific community for novel research, promotes cardiovascular health in the local
community, and encourages underrepresented minority students to pursue biomedical careers.
is a longitudinal investigation of genetic and environmental risk factors associated with the
disproportionate burden of cardiovascular disease (CVD) in African-Americans. In addition,
the JHS conducts community education and outreach activities to promote healthy lifestyles
and reduce disease risk burden, undergraduate- and graduate-level research training programs,
and high school science and math enrichment programs to prepare and encourage
underrepresented minority students to pursue biomedical careers.
(www.jacksonheartstudy.org/). The JHS represents an expansion of the Jackson Field Center of
the Atherosclerosis Risk in Communities (ARIC) study (http://www2.cscc.unc.edu/aric/), to
broaden data collection in an African- American population and to increase access to and
participation of African American populations and scientists in biomedical research and
professions. The study recruited 5306 African-American residents living in the Jackson, MS,
metropolitan statistical area (MSA) of Hinds, Madison, and Rankin Counties. Participants were
enrolled from each of 4 recruitment pools: random, 17%; volunteer, 30%; currently enrolled in
the Atherosclerosis Risk in Communities (ARIC) Study, 31% (shared JHS/ARIC cohort); and
secondary family members, 22%. Recruitment was limited to non-institutionalized adult African
Americans 35-84 years old, except in a nested family cohort where those 21 to 34 years of age
were also eligible. The final cohort of participants included 6.59% of all African American
Jackson MSA residents aged 35-84 during the baseline exam (N-76,426, US Census 2000). Among
these, approximately 3,700 gave consent that allows genetic research and deposition of data
into dbGaP. Enrolled JHS participants received three back-to-back clinical examinations (Exam
1, 2000-04; Exam 2, 2005-08; and Exam 3, 2009-13) that have generated extensive longitudinal
data on: traditional and putative CVD risk factors, socioeconomic and sociocultural factors,
and biochemical analytes; and measures of subclinical disease from echocardiography, cardiac
magnetic resonance imaging (MRI), and computed tomography (CT) scans of the heart, aorta, and
abdomen. Stored biological samples have been assayed for putative biochemical risk factors
and stored for future research. DNA has been extracted and lymphocytes cryopreserved for
study of candidate genes, genome-wide scanning, expression, and other -omics investigations.
Participants have been contacted annually to: update information; confirm vital statistics;
document interim medical events, hospitalizations, and functional status; and obtain
additional sociocultural information. Ongoing cohort surveillance includes abstraction of
medical records and death certificates for relevant International Classification of Diseases
(ICD) codes and adjudication of nonfatal events and deaths. The JHS serves as a resource to
the scientific community for novel research, promotes cardiovascular health in the local
community, and encourages underrepresented minority students to pursue biomedical careers.
Inclusion Criteria:
- African American
- Residents of Jackson, Mississippi
Exclusion Criteria:
- Institutionalization
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