To Determine the Safety, Tolerability, Pharmacokinetics and Effect on Pain of a Single Intra-articular Administration of Canakinumab in Patients With Osteoarthritis in the Knee



Status:Archived
Conditions:Arthritis, Osteoarthritis (OA)
Therapuetic Areas:Rheumatology
Healthy:No
Age Range:Any
Updated:7/1/2011
Start Date:April 2010

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A Randomized, Double Blind, Placebo and Naproxen Controlled, Multi-center, Study to Determine the Safety, Tolerability, Pharmacokinetics and Effect on Pain of a Single Intra-articular Administration of Canakinumab in Patients With Osteoarthritis in the Knee


The study will determine whether the ability of canakinumab to inhibit IL-1β activity for
sustained time-periods with a favorable impact on the three critical parameters of OA
symptoms, namely 1) pain 2) function and 3) stiffness. These outcomes will be compared to
placebo.



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Westlake Village, California 91361
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175 Meadowbrook Lane
, Pennsylvania 16635
814-693-0300
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Anniston, Alabama 36207
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1653 W. Congress Parkway
Chicago, Illinois 60612
(312) 942-5000
Rush University Medical Center Rush University Medical Center encompasses a 664-bed hospital serving adults and...
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Knoxville, Tennessee 37920
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Mesa, AZ
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San Diego, CA
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Topeka, KS
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