Genetic Epidemiology of Primary Biliary Cirrhosis (PBC)
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Gastrointestinal |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | 18 - 90 |
| Updated: | 12/13/2018 |
| Start Date: | March 2002 |
| End Date: | December 2025 |
Understanding the Genetic Predisposition to the Development of Primary Biliary Cirrhosis (PBC).
Primary Biliary Cirrhosis (PBC) is a progressive liver disorder of unknown cause. Current
evidence suggests that genes, the genetic material we inherit from our parents, in
combination with environmental factors, likely play an important role in the development of
PBC.
This study is being done to investigate whether genes make people more likely to develop PBC.
Discovery of these proposed genes will help us better understand how PBC developes, and
subsequently, to apply new approaches for its prevention, diagnosis and treatment.
evidence suggests that genes, the genetic material we inherit from our parents, in
combination with environmental factors, likely play an important role in the development of
PBC.
This study is being done to investigate whether genes make people more likely to develop PBC.
Discovery of these proposed genes will help us better understand how PBC developes, and
subsequently, to apply new approaches for its prevention, diagnosis and treatment.
Inclusion Criteria:
- Men and women between the ages of 18-90 who have a history of PBC.
- PBC patients who have undergone a liver transplant are eligible.
- Family members (1st degree relatives) of enrolled PBC patients are eligible.
Exclusion Criteria:
- Individuals with no history of PBC or those unable to provide consent.
We found this trial at
1
site
Rochester, Minnesota 55905
Principal Investigator: Konstantinos N Lazaridis, M.D.
Phone: 507-284-4312
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