Intravitreal Ketorolac for Chronic Uveitis: A Investigational Safety Study
| Status: | Completed |
|---|---|
| Conditions: | Ocular |
| Therapuetic Areas: | Ophthalmology |
| Healthy: | No |
| Age Range: | 18 - 90 |
| Updated: | 12/28/2013 |
| Start Date: | December 2009 |
| End Date: | December 2010 |
Intravitreal Ketorolac for Chronic Uveitis:A Phase I Investigational Safety Study
Intraocular delivery of ketorolac will be an effective means to treat inflammation and
macular edema and prevent structural complications and vision loss in patients with uveitis
who are unable to tolerate corticosteroids due to their side effects.
macular edema and prevent structural complications and vision loss in patients with uveitis
who are unable to tolerate corticosteroids due to their side effects.
A Phase I safety study of intravitreal ketorolac in patients with chronic inflammation and
complications due to inflammation who have either failed medical therapy or who cannot
tolerate corticosteroids due to side effects.
Specific Aims
1. Test the safety of intraocular injection of 4mg of ketorolac in patients who have
intractable uveitis or complications of uveitis such as chronic macular edema who are
unable to tolerate corticosteroids due to their side effects.
2. Test the efficacy of intraocular 4m ketorolac of treating inflammation or structural
complications of inflammation in patients with uveitis who are unable to tolerate
corticosteroids due to their side effects.
complications due to inflammation who have either failed medical therapy or who cannot
tolerate corticosteroids due to side effects.
Specific Aims
1. Test the safety of intraocular injection of 4mg of ketorolac in patients who have
intractable uveitis or complications of uveitis such as chronic macular edema who are
unable to tolerate corticosteroids due to their side effects.
2. Test the efficacy of intraocular 4m ketorolac of treating inflammation or structural
complications of inflammation in patients with uveitis who are unable to tolerate
corticosteroids due to their side effects.
Inclusion Criteria:
- Adult volunteers
- Chronic intractable uveitis or chronic complications of uveitis (macular
edema)despite maximal medical treatment
- Unable to tolerate corticosteroids due to side effects
Exclusion Criteria:
- 18 years or younger
- Have active ocular infection
- Pregnancy
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